The TNF Superfamily

• autonomous and non-cell-autonomous functions of caspase-8
• Crosstalk via the NF-κB signaling system
• Immune regulation and control of regulatory T cells by OX40 and 4-1BB
• microRNAs and death receptors
• Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade
• Rheumatoid polyarthritis caused by a defect in DNA degradation
• Roles of TRAF molecules in B lymphocyte function
• TACI, an enigmatic BAFF-APRIL receptor, with new unappreciated biochemical and biological properties
• Targeting the extrinsic apoptosis pathway in cancer
• Targeting tumors with LIGHT to generate metastasis-clearing immunity
• The TNF receptor and Ig superfamily members form an integrated signaling circuit controlling dendritic cell homeostasis
• The TNF Superfamily-2008
• TNF superfamily in skin appendage development
• Troy-Taj and its role in CNS axon regeneration
• Ubiquitin-mediated regulation of TNFR1 signaling

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Travelling with the BAFF-BLyS Family

• Travelling with the BAFF-BLyS family
• The role of the BAFF-APRIL system on T cell function
• Regulation of B cell self-tolerance by BAFF
• Impact of the BAFF-BR3 axis on B cell survival, germinal center maintenance and antibody production
• BLyS receptor signatures resolve homeostatically independent compartments among naive and antigen-experienced B cells
• BLyS and B cell homeostasis
• BAFF, APRIL and their receptors
• BAFF, APRIL and human B cell disorders

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Autoantibodies and Autoimmunity

• Urinary biomarkers in lupus nephritis
• The Ro 60 kDa autoantigen comes into focus-Interpreting epitope mapping experiments on the basis of structure
• The genetic basis of autoantibody production
• T cell-mediated activation and regulation of anti-chromatin B cells
• Role of non-protein amino acid l-canavanine in autoimmunity
• Role of B-1a cells in autoimmunity
• Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
• Regulation of Fli1 gene expression and lupus
• Ninth International Workshop on Autoantibodies and Autoimmunity
• Liver stem cell-derived β-cell surrogates for treatment of type 1 diabetes
• FoxP3-A genetic link between immunodeficiency and autoimmune diseases
• Dendritic cell subsets and type I diabetes
• Autoantibody markers for the diagnosis and prediction of type 1 diabetes

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Antigen processing and presentation

• Antigen processing and presentation
• Viral modulation of antigen presentation
• The seven dirty little secrets of major histocompatibility complex class I antigen processing
• The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II-peptide complexes
• The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex
• The lysosomal cysteine proteases in MHC class II antigen presentation
• the beginning, the middle, and the end of the MHC class I antigen-processing pathway
• studying post-proteasomal proteolysis in HLA class I antigen presentation
• Right place, right time, right peptide-DO keeps DM focused
• Recognition of open conformers of classical MHC by chaperones and monoclonal antibodies
• Phagocytosis-the convoluted way from nutrition to adaptive immunity
• MHC class I alleles and their exploration of the antigen-processing machinery
• Mechanisms of MHC class I-restricted antigen processing and cross-presentation
• Interferon-y, the functional plasticity of the ubiquitin–proteasome system, and MHC class I antigen processing
• Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases
• Dendritic cells, DRiPs, and DALIS in the control of antigen processing
• Cross-presentation-underlying mechanisms and role in immune surveillance
• Control of MHC class II antigen presentation in dendritic cells
• Conformational isomers of a peptide–class II major histocompatibility complex
• Compartmentalization of class II antigen presentation-contribution of cytoplasmic and endosomal processing
• Asparaginyl endopeptidase-case history of a class II MHC compartment protease
• Achieving stability through editing and chaperoning-regulation of MHC class II peptide binding and expression
• Accessory molecules in the assembly of major histocompatibility complex class I-peptide complexes

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Autoimmunity

• Tumor necrosis factor family members and inflammatory bowel disease
• Toll-like receptors, endogenous ligands, and systemic autoimmune disease
• The stages of type 1A diabetes
• The role of BAFF in immune function and implications for autoimmunity
• The regulation and activation of lupus-associated B cells
• The B7-CD28 costimulatory family in autoimmunity
• T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens
• Rheumatoid arthritis
• Regulatory T cells and intestinal homeostasis
• Regulatory T cells and autoimmune disease
• Protein arrays for studying blood cells and their secreted products
• Pathways to gene identification in rheumatoid arthritis-PTPN22 and beyond
• Multiple sclerosis
• Interferons as pathogenic effectors in autoimmunity
• immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice
• Genetic progress towards the molecular basis of autoimmunity
• Genetic lesions in T-cell tolerance and thresholds for autoimmunity
• CTLA4 gene polymorphism and autoimmunity
• AIRE and APECED-molecular insights into an autoimmune disease
• Autoimmunity

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Signal Processing in the Immune System

• Signal Processing in the Immune System
• The role of supramolecular protein complexes and membrane potential in transmembrane signaling processes of lymphocytes
• The multiple function of Grb2 associated binder (Gab) adaptor-scaffolding protein in immune cell signaling
• Still waiting for the toll
• ITAM-based signaling beyond the adaptive immune response
• involvement of selectins and their ligands in tumor-progression
• Inflammation and the apopto-phagocytic system
• How antibodies act as natural adjuvants
• Germline and somatic diversification of immune recognition elements in Metazoa
• Expression and role of Fc-and complement-receptors on human dendritic cells
• Cytokine mediated induction of the major Epstein–Barr virus (EBV)-encoded transforming protein, LMP-1
• Cholesterol and sphingolipids as lipid organizers of the immune cells’ plasma membrane
• Breaking or making immunological privilege in the central nervous system
• B7-1 and B7-2-Similar costimulatory ligands with different biochemical, oligomeric and signaling properties

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Osteoimmunology

• Osteoimmunology
• The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function
• The role of the immune system in the pathophysiology of osteoporosis
• The role of T lymphocytes in bone metabolism
• The role of immune cells and inflammatory cytokines in Paget's disease and multiple myeloma
• Skeletal development, bone remodeling, and hematopoiesis
• Role of RANKL in physiological and pathological bone resorption and therapeutics targeting
• Role of nuclear factor-kB in the immune system and bone
• Role of ITAM-containing adapter proteins and their receptors in the immune system and bone
• Role of interleukin-7 in bone and T-cell homeostasis
• Rheumatic diseases-the effects of inflammation on bone
• Osteoclast precursors, RANKL-RANK, and immunology
• Microgravity-the immune response and bone
• Interplay between interferon and other cytokine systems in bone metabolism
• Immune responses and bone loss
• Fos-AP-1 proteins in bone and the immune system
• counter-regulatory mechanisms in bone and adaptive immunity
• B cells and osteoblast and osteoclast development
• avb3 and macrophage colony-stimulating factor-partners in osteoclast biology

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Molecular basis of immunodeficiency

• Studies of patients' thymi aid in the discovery and characterization of immunodeficiency in humans
• Severe combined immunodeficiency. A model disease for molecular immunology and therapy
• Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis
• Molecular and cellular pathogenesis of X-linked lymphoproliferative disease
• Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs
• Interleukin-7 receptor a (IL-7Ra) deficiency
• Inherited disorders of human Toll-like receptor signaling
• Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects
• Hyper-IgE syndromes
• Hyper immunoglobulin M syndrome due to CD40 deficiency
• Human disease resulting from gene mutations that interfere with appropriate nuclear factor-kB activation
• Genetic analysis of patients with defects in early B-cell development
• FOXP3 acts as a rheostat of the immune response
• DNA deamination in immunity
• Defects in the interferon-y and interleukin-12 pathways
• CXCR4 mutations in WHIM syndrome
• Bruton's tyrosine kinase-cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
• Molecular basis of immunodeficiency

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Lymphoproliferative disorders

• Lymphoproliferative disorders
• Viruses and lymphoma
• Organisation of neoplastic haematopathology services
• Molecular biology of lymphoma in the microarray era
• Lymphoproliferative disorders-prospects for gene therapy
• Immunophenotyping of lymphoproliferative disorders
• epidemiology of non-Hodgkin lymphoma
• Diagnostic pathology of lymphoproliferative disorders
• Cytogenetics of lymphomas

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Genomics & proteomics

• Genomics & proteomics-reduce,rebuild, reveal
• Use of baculovirus MHC-peptide display libraries to characterize T-cell receptor ligands
• Transcriptional basis of lymphocyte tolerance
• The plasticity of immunoglobulin gene systems in evolution
• Phospho-proteomic immune analysis by flow cytometry
• Microarray-based understanding of normal and malignant plasma cells
• Identifying susceptibility genes for immunological disorders
• identifying genes that regulate organ-specific and systemic autoimmunity
• Gene expression profiling in human autoimmunity
• Functional genomics and proteomics for infectious diseases
• Circuitry of nuclear factor kB signaling
• Chipping into the human genome-novel insights for transplantation
• Charting protein complexes, signaling pathways, and networks in the immune system
• A shared gene-expression signature in innate-like lymphocytes
• A library of gene expression signatures to illuminate normal and pathological lymphoid biology

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Specialized Immunological Niches

• The right place at the right time
• Thymic microenvironments for T cell differentiation and selection
• The sense of place in the immune system
• The hematopoietic stem cell in its place
• See no evil, hear no evil, do no evil the lessons of immune privilege
• Lymphoid organ development from ontogeny to neogenesis

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Lymphocyte development

• Lymphocyte development
• Transcription factors drive B cell development
• The why and how of thymocyte negative selection
• T lineage progenitors
• Regulation of V(D)J recombination
• Receptor editing for better or for worse
• Lysine methylation and ‘signaling memory’
• Gene regulatory networks and the determination of lymphoid cell fates
• Chromatin structure and gene regulation in T cell development and function
• CD4-CD8 lineage commitment
• AID in somatic hypermutation and class switch recombination
• Thymocyte motility

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Regulatory T Cells

• Regulatory T cells
• Clinical application of expanded CD4+25+ cells
• Instruction of Treg commitment in peripheral T cells is suited to reverse autoimmunity
• The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity
• Antigen-specific regulatory T cells—Ex vivo expansion and therapeutic potential
• Regulatory T cells in transplantation
• Tr1 cells-From discovery to their clinical application
• CD4+CD25+ regulatory T lymphocytes in bone marrow transplantation
• Regulatory T cells and Toll-like receptors in tumor immunity

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Dendritic cell heterogeneity

• Plasmacytoid dendritic cells
• Phenotype and function of intestinal dendritic cells
• Monocyte-derived dendritic cells
• Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells
• Heterogeneity of thymic dendritic cells
• Dendritic cell subsets and immune regulation in the lung
• Cutaneous dendritic cells
• Developmental plasticity and functional diversity

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Pathogen interactions in the 21st century

• Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea
• Viral and host factors in the pathogenesis of HIV infection
• sars-Pathogenesis of severe acute respiratory syndrome
• Pathogenesis of viral hemorrhagic fever
• Pathogen recognition with Toll-like receptors
• NOD proteins
• Levels of complexity in pathogen recognition by C-type lectins
• Interactions between malaria parasites and the host immune system
• Host innate and Th1 responses and the bacterial factors that control Mycobacterium tuberculosis infection
• Alarmins-chemotactic activators of immune responses
• Host–pathogen interactions in the 21st century

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Complement

• Strategies of therapeutic complement inhibition
• Receptors for complement C3 on T-lymphocytes
• Liver inflammation and regeneration
• complement system in the pathophysiology of pregnancy
• Complement escape of human pathogenic bacteria by acquisition of complement regulators
• Complement deficiency and disease
• Complement and Toll-like receptors
• Complement and diseases
• Complement and complement regulators in the male reproductive system
• Clinical manifestations of mannan-binding lectin deficiency
• Complement amplification revisited

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Pathogen interactions

• Virulence factors, pathogenesis and vaccine protection in cholera and ETEC diarrhea
• Viral and host factors in the pathogenesis of HIV infection
• Vaccinology at the beginning of the 21st century
• sars-Pathogenesis of severe acute respiratory syndrome
• Pathogenesis of viral hemorrhagic fever
• Pathogen recognition with Toll-like receptors
• NOD proteins-an intracellular pathogen-recognition system or signal transduction modifiers
• Levels of complexity in pathogen recognition by C-type lectins
• Interactions between malaria parasites and the host immune system
• Alarmins-chemotactic activators of immune responses
• Host–pathogen interactions in the 21st century

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Intestinal epithelial barrier and mucosal immunity

• IOral tolerance and regulation of mucosal immunity
• IOntogeny of intestinal epithelium immune functions
• Innate and acquired plasticity of the intestinal
• Imarvel of mucosal T cells and secretory antibodies for the creation of first lines of defense
• IInnate immune relationship between commensal flora and the mammalian intestinal epithelium
• IInnate defenses of the intestinal epithelial barrier
• IContribution of microbial-associated molecules in innate mucosal responses

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Immunological techniques

• Working with NKT cells-pitfalls and practicalities
• Molecular tracking of antigen-specific T-cell clones during immune responses
• MHC multimer technology
• Gene profiling of immune responses against tumors
• Ex vivo analysis of T-cell function
• Ex vivo characterization of T cell-mediated immune responses in cancer

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免疫耐受

• Autoimmunity-Cellular and genetic mechanisms of self tolerance and autoimmunity
• Autoimmunity-T cell tolerance and autoimmunity
• B Cells and Alloantibodies in Tolerance
• Dendritic cells as therapeutic vaccines against cancer
• Dominant tolerance-activation thresholds for peripheral generation of regulatory T cells
• Embryonic stem cells-a novel source of dendritic cells for clinical applications
• Immune response versus mucosal tolerance to mucosally administered antigens
• Immunosuppression
• Immunosuppressive Drugs and the Risk of Cancer after Organ Transplantation
• Immunosuppressive Drugs for Kidney Transplantation
• Immunosuppressive networks in the tumour environment and their therapeutic relevance
• Induction of tolerance using Fas ligand
• Is B Cell Tolerance Essential for Transplantation Tolerance
• Mixed Hematopoietic Chimerism for the Simultaneous Induction of T and B Cell Tolerance
• Molecular Mechanisms Regulating B Cell Responsiveness and Tolerance
• Mucosal immunity and tolerance in the elderly
• Natural regulatory T cells and self-tolerance
• Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self
• Neonatal Tolerance Induction by Repetitive DNA Vaccination
• New technologies for organ replacement and augmentation
• Peripheral tolerance of CD8 T lymphocytes
• Prope tolerance—the future of organ transplantation from the laboratory to the clinic
• Sinks, suppressors and antigen presenters
• The road to tolerance
• Tolerance in mixed chimerism – a role for regulatory cells
• Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions
• Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity

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Counting on Homeostasis

• The CD8 memory T cell subsystem
• T cell homeostasis
• Regulation of mature T cell homeostasis
• Models for peripheral B cell development and homeostasis
• Homeostatic proliferation of B cells
• Homeostasis of T cell numbers
• Endogenous proliferation-Burst-like CD4 T cell proliferation in lymphopenic settings
• Counting on homeostasis governing the size and composition of lymphocyte pools

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Food allergy

• update on developing therapies for peanut allergy
• The oral allergy syndrome
• Primary prevention of food allergy in infants who are at risk
• Nonspecific lipid-transfer proteins in plant foods and pollens
• Genetic and environmental risk factors for the development of food allergy
• Food allergy diagnostics
• Emergency management of food allergy
• Anisakis simplex
• Food allergy

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Gene Silencing in Lymphocyte Development

• The λ5–VpreB1 locus—a model system for studying gene regulation
• MicroRNAs as regulators of mammalian hematopoiesis
• Immunoglobulin locus silencing and allelic exclusion
• Epigenetic control of B cell differentiation
• DNA methylation and the expanding epigenetics of T cell lineage commitment
• Assembly of silent chromatin during thymocyte development
• Gene silencing in lymphocyte development

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Innate immunity in health and disease

• Type I interferons and the innate immune response—more than just antiviral cytokines
• The role of Toll-like receptors in the host response to viruses
• Mannose-binding lectin
• Intestinal epithelial Tollerance versus inTollerance of commensals
• Innate immunity-past, present and future
• Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori
• Innate immune defence in the human gastrointestinal tract
• Gliadin as a stimulator of innate responses in celiac disease
• Bacterial modulation of mucosal innate immunity
• Anticipating innate immunity without a Toll
• Innate immunity in health and disease

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Antigen and DNA delivery systems for vaccines

• Virosomes for antigen and DNA delivery
• PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines
• Need for new vaccine formulations and potential of particulate antigen and DNA delivery systems
• ISCOMATRIX adjuvant for antigen delivery
• Immunity in response to particulate antigen-delivery systems
• Formulation aspects of biodegradable polymeric microspheres for antigen delivery
• Exploiting receptor biology for oral vaccination with biodegradable particulates
• DNA-loaded biodegradable microparticles as vaccine delivery systems
• Biodegradable poly(lactic-co-glycolic acid) microparticles for injectable delivery of vaccine antigens
• Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery
• vaccine-antigen and DNA delivery systems for vaccines

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Gene silencing in lymphocyte development

• The λ5–VpreB1 locus—a model system for studying gene regulation during early B cell development
• MicroRNAs as regulators of mammalian hematopoiesis
• Immunoglobulin locus silencing and allelic exclusion
• Epigenetic control of B cell differentiation
• DNA methylation and the expanding epigenetics of T cell lineage commitment
• Assembly of silent chromatin during thymocyte development
• Gene silencing in lymphocyte development

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Spatial organization in immune cell signaling

• Thymopoiesis in 4 dimensions
• the organization of membrane proximal signaling
• T cell synapse assembly
• Single-molecule tracking of membrane molecules
• Multi-chain immune recognition receptors
• Lipid rafts and the initiation of T cell receptor signaling
• immune cell polarization and chemotaxis
• CTL secretory lysosomes
• Spatial organization in immune cell signaling

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Innate immunity

• Sensing and signaling during infection in Drosophila
• NK cells in innate immunity
• Manipulation of innate immunity by bacterial pathogens
• Ligand recognition by antigen-presenting cell C-type lectin receptors
• Genetic dissection of innate immunity to infection
• Evolutionary perspectives on innate immunity from the study of Caenorhabditis elegans
• Innate immunity
• an overview
• from lymphocyte mitogens to Toll-like receptors and back
• TLR signalling
• DCs Tip off the innate immune system
• DCs the immune systems flexible friend
• Sensing The Environment And Regulating The Regulators
• Using the World Wide Web for predicting CTL epitopes
• Transcriptional regulation of the MHC class II antigen presentation pathway
• Ringing the interferon alarm-differential regulation of gene expression at the interface between innate and adaptive immunity
• Resistance gene signaling in plants-complex similarities to animal innate immunity
• Natural killer cells and viral infections
• Macrophage regulation by Tyro 3 family receptors
• ISO-a critical evaluation of the role of peptides in heat shock-chaperone protein-mediated tumor rejection
• Interaction of bacteria with antigen presenting cells
• Epitope dominance, competition and T cell affinity maturation
• Death and survival-viral regulation of TNF signaling pathways
• Cross priming or direct priming
• ck-New insights into the mechanism of IL-1β maturation
• CD1-restricted antigen presentation
• Assembly and export of MHC class I peptide ligands
• Antigen processing and recognition

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Adaptors in immnue regulation

• Transmembrane adapters
• The SLP-76 family of adapter proteins
• The SAP family of adaptors in immune regulation
• The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling
• Regulation of the immune system by SOCS family adaptor proteins
• Involvement of the Wiskott-Aldrich syndrome protein and other actin regulatory adaptors in T cell
• Inhibitory adaptors in lymphocytes
• Adaptors in immune regulation

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补体

• The human complement factor H- functional roles, genetic variations and disease associations
• The complement system in B cell regulation
• The alternative pathway of complement in disease
• Primitive complement system—recognition and activation
• Mannan-binding lectin—a soluble pattern recognition molecule
• Initiation of complement activation following oxidative stress
• Dendritic cells and complement- at the cross road of innate and adaptive immunity
• anaphylatoxins bridge innate and adaptive immune responses in allergic asthma
• a cross-disciplinary approach to complement-mediated functions

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Making Peptides for Presentation

• Making Peptides for Presentation－Research Highlights
• Post-proteasomal antigen processing for major histocompatibility complex class I presentation
• Generation of major histocompatibility complex class I antigens
• exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
• Cellular mechanisms governing cross-presentation of exogenous antigens
• Making Peptides for Presentation

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Antiviral immunity

• Role of T cell costimulation in anti-viral immunity
• Lessons from the study of T-cell differentiation in persistent human virus infection
• Immunological memory in humans
• DC-virus interplay
• Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model
• CD4 T cell responses to influenza infection
• Anatomical features of anti-viral immunity in the respiratory tract
• Antiviral immunity

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HIV

• Prospects for an AIDS vaccine
• Plasma Ascorbate Deficiency Is Associated With Impaired Reduction of Sulfamethoxazole-Nitroso in HIV Infection
• Long-Term Efficacy of Routine Access to Antiretroviral-Resistance Testing in HIV Type 1-Infected Patients Results of the Clinical Efficacy of Resistance Testing Trial
• Immunological and virological study of enfuvirtide-treated HIV-positive patients
• Immune restoration disease after antiretroviral therapy
• Differences in HIV RNA levels before the initiation of antiretroviral therapy among 1864 individuals with known HIV-1 seroconversion dates
• Comprehensive Pediatric Human Immunodeficiency Virus Care and Treatment in Constanta, Romania Implementation of a Program of Highly Active Antiretroviral Therapy in a Resource-Poor Setting
• Asia and Africa-The Asian Epidemic Model a process model for exploring HIV policy and programme alternatives in Asia
• HIV and hepatitis C virus co-infection
• The AIDS Epidemic in 2004
• The viral infectivity factor (Vif) of HIV-1 unveiled
• The molecular basis of HIV capsid assembly
• The AIDS Epidemic in 2004
• Prospects for an AIDS vaccine
• HIV and hepatitis C virus co-infection
• Efficacy of an HIV Prevention Intervention for African American Adolescent Girls- A Randomized Controlled Trial
• An Update on Management of Persons with Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome

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Food allergy

• Update on threshold doses of food allergens
• Seafood allergy
• Pathophysiology, diagnosis and treatment of food protein-induced gastrointestinal diseases
• Do we have suitable in-vitro diagnostic tests for the diagnosis of food allergy
• Clinical importance of cross-reactivity in food allergy
• what do we learn from animal models
• The mechanism of food allergy

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Family of the IL-10

• Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
• Interleukin-26
• Interleukin-22 activates STAT3 and induces IL-10 by colon epithelial cells
• Interleukin-20
• IL-24 is a unique cytokine–tumor suppressor in the IL-10 Family
• IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues
• Human interleukin-19 and its receptor
• Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization
• Cytokine and tumor cell apoptosis inducing activity of mda-7-IL-24
• 12 receptors for 27 cytokines

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Signal Processing in the Immune System

• Signal Processing in the Immune System
• Transmembrane adaptor proteins in membrane microdomains
• The Fc receptor for IgA
• T cell contributions to the different phases of granuloma formation
• Speculations on the origin of the vertebrate immune system
• Regulation of mast cell activation by complement-derived peptides
• New phenotypic, functional and electrophysiological characteristics of KG-1 cells
• Killer cell immunoglobulin-like receptor diversity-balancing signals in the natural killer cell response
• Ion channels and lymphocyte activation
• IgG-and IgE-mediated antigen presentation on MHC class II
• How T cells use LFA-1 to attach and migrate
• Functional consequences of a MAPK docking site on human FcRIIb
• Down-modulation of the antigen receptor by a superantigen for human B cells
• Dendritic cells in the initiation of immune responses against central nervous system-derived antigens
• Cysteine-dependent immune regulation by TRX and MIF-GIF family proteins
• CD45 isoforms in T cell signalling and development
• Bruton's tyrosine kinase (Btk)---Cthe critical tyrosine kinase in LPS signalling
• B cell antigen receptor assembly and Syk activation in the S2 cell reconstitution system
• Autonomous SHIP-dependent FcR signaling in pre-B cells leads to inhibition of cell migration and induction of cell death

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Cellular Invasions

• Cellular Invasions
• Intracellular Parasite Invasion Strategies
• How Viruses Enter Animal Cells
• Bacterial Invasion-The Paradigms of Enteroinvasive Pathogens
• Ancient Invasions-From Endosymbionts to Organelles

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Regulatory T Cells

• Regulatory T Cells
• Role of dendritic cells in the generation of regulatory T cells
• Regulatory T cells generated ex vivo as an approach for the therapy of autoimmune disease
• Regulatory T cells and organ transplantation
• Pharmacological induction of tolerogenic dendritic cells and regulatory T cells
• Naturally-occurring CD4+CD25+ immunoregulatory T cells
• Molecular aspects of regulatory T cell development
• Human CD4+CD25+ regulatory T cells
• Antigen-specific regulatory T cells--Ctheir induction and role in infection
• Immunoregulatory T cells in tumor immunity

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The Immunological Synapse

• The role of the secretory immunological synapse in killing by CD8+ CTL
• The protean immune cell synapse
• Linking molecular and cellular events in T-cell activation and synapse formation
• B lymphocyte activation during cognate interactions with CD4+ T lymphocytes
• The Immunological Synapse

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Apoptotic Signaling Pathways in the Immune System

• apoptotic signaling pathways in the immune system
• Activation-induced cell death in T cells
• Apoptosis and transplantation tolerance
• Apoptosis, tolerance, and regulatory T cells
• Caspase-activation pathways in apoptosis and immunity
• Caspases and T lymphocytes
• Death and Baxes- mechanisms of lymphotrophic cytokines
• Granzyme B- a natural born killer
• Neutrophil apoptosis pathways and their modifications in inflammation
• Regulation of apoptosis by ubiquitination
• The control of apoptosis in lymphocyte selection
• The role of CD95 in the regulation of peripheral T-cell apoptosis
• Transducing signals from antigen receptors to nuclear factor B

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Gene Therapy＆Immunopathology

• Adaptive and innate immune responses to gene transfer vectors
• Celiac Disease-a model autoimmune disease with gene therapy applications
• Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells
• Engineering mesenchymal stem cells for immunotherapy
• Gene- and cell-based therapeutics for type I diabetes mellitus
• Gene therapy for arthritis
• Gene therapy in autoimmune, demyelinating disease of the central nervous system
• Gene therapy in nonhuman primate models of human autoimmune disease
• Gene transfer approaches for the treatment of inflammatory bowel disease
• Immune response following intraocular delivery of recombinant viral vectors
• -Immune responses to adeno-associated virus and its recombinant vectors
• Immune responses to replication-defective HSV-1 type vectors within the CNS- implications for gene therapy
• Immunity to adenovirus and adeno-associated viral vectors
• Immunopathology and the gene therapy of lupus
• Inflammation and adaptive immune responses to adenoviral vectors injected into the brain
• Molecular basis of the inflammatory response to adenovirus vectors
• Vectors for the treatment of autoimmune disease
• gt-immune-introduction-Virology and immunology of gene therapy

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Supprsessor of cytokine signaling

• SOCS with function
• SOCS3 negatively regulates IL-6 signaling in vivo
• SOCS3 regulates the plasticity of gp130 signaling
• IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
• A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
• A New Role for SOCS in Insulin Action
• A Role of Suppressor of Cytokine Signaling 3
• Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling
• Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
• Interleukin-4 and Interleukin-13 Signaling Connections Maps
• Interleukins in Atherosclerosis
• Janus Kinase-STAT Inflammatory Signaling through Induction of SOCS1 and SOCS3
• MOLECULAR MECHANISMS REGULATING TH1 IMMUNE RESPONSES
• Negative Regulation of Interleukin-12 Signaling by Suppressor of Cytokine Signaling-1
• nterleukin-6 inhibits hepatic growth hormone signaling via upregulation of Cis and Socs-3
• PDGF stimulates pulmonary vascular smooth muscle cell proliferation by upregulating TRPC6 expression
• Pim serine-threonine kinases regulate the stability of Socs-1 protein
• Regulation of Jak2 through the Ubiquitin-Proteasome Pathway -Interaction with SOCS
• SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling
• Signaling and Transcription in T Helper Development
• SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth
• Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Cytokines in Peripheral T Cells
• Suppressor of Cytokine Signaling-1 Regulates the Sensitivity of Pancreatic Cells to Tumor Necrosis Factor
• Suppressor of Cytokine Signaling-3 (SOCS-3),
• The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress

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Cell Death and Immunity

• Apoptosis as an HIV strategy to escape immune attack
• Apoptosis in the development and maintenance of the immune system
• Caspase-independent cell death in T lymphocytes
• Delivering the kiss of death
• Negative selection - clearing out the bad apples from the T-cell repertoire
• NODS-intracellular proteins involved in inflammation and apoptosis
• Summaries of recent papers on cell death
• The ABCs of granule-mediated cytotoxicity-new weapons in the arsenal

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Notch signalling in the immune system

• Notch signalling in the immune system
• A Notch so simple influence on T cell development
• An overview of the Notch signalling pathway
• Notch signaling in lymphocyte development
• Notch signalling at the crossroads of T cell development and leukemogenesis
• Notch signalling in B cells
• Notch signalling in hematopoiesis
• Notch signalling in the regulation of peripheral T-cell function

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Regulatory lymphocytes

• ANTIGEN-INDUCED REGULATORY T CELLS IN AUTOIMMUNITY
• AUTOREACTIVITY BY DESIGN- INNATE B AND T LYMPHOCYTES
• CYTOKINES AND AUTOIMMUNITY
• cytokines and the control of lymphoid homeostasis
• Direct DC hit activates TReg cells
• IMMUNOREGULATION IN THE TISSUES BY γδ T CELLS
• JANUS-LIKE ROLE OF REGULATORY INKT CELLS IN AUTOIMMUNE DISEASE AND TUMOUR IMMUNITY
• NATURAL VERSUS ADAPTIVE REGULATORY T CELLS
• REGULATORY T CELLS IN TRANSPLANTATION TOLERANCE
• REGULATORY T CELLS UNDER SCRUTINY
• T-CELL REGULATION BY CD28 AND CTLA-4

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Vaccines and Vaccination in 21st

• vaccine-How Contagious Is Vaccinia
• vaccine-New tendencies and strategies in international immunisation
• vaccine-Novel approaches in the development of immunopotentiating reconstituted influenza virosomes
• vaccine-Primary prevention of hepatitis C virus infection
• vaccine-Progress in DNA vaccine for prophylaxis and therapy of hepatitis B
• vaccine-Prospects and challenges for prophylactic and therapeutic HIV vaccines
• vaccine-Recent progress in the development of vaccines for infants and children
• vaccines and vaccination in the 21st century-
• vaccines and vaccination in the 21st century-Aspects of cancer immunotherapy
• vaccines and vaccination in the 21st century-Bacterial otitis media- Current vaccine development strategies
• vaccines and vaccination in the 21st century-CPG ODN allows lower dose of antigen against hepatitis B surface antigen in BALBc mice
• vaccines and vaccination in the 21st century-Generation of CTL responses using Kunjin replicon RNA
• vaccines and vaccination in the 21st century-Hypoallergenic derivatives of major grass pollen allergens for allergy vaccination
• vaccines and vaccination in the 21st century-Immune responses in hepatitis C virus infection
• vaccines and vaccination in the 21st century-Immune responses to hepatitis B surface antigen following epidermal powder immunization
• vaccines and vaccination in the 21st century-Improving vaccines against tuberculosis
• vaccines and vaccination in the 21st century-Maturation of dendritic cells with lipopeptides that represent vaccine candidates for hepatitis C virus
• vaccines and vaccination in the 21st century-Mucosal immunity
• vaccine-Structural evidence for substrate strain in antibody catalysis
• vaccine-The global value of vaccination
• vaccine-The rationale of a peptide-conjugate vaccine against measles
• vaccine-Therapeutic vaccination for future management of HIV-AIDS
• vaccine-Two years into reverse vaccinology
• vaccine-Vaccinology- past achievements, present roadblocks and future promises
• vaccine-Virus-like particle and DNA-based candidate AIDS vaccines
• vacc-ne-V-1 Immunitor- oral therapeutic AIDS vaccine with prophylactic potential

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Monoclonal Antibody

• Antibody manufacture in transgenic animals and comparisons with other systems
• endocrin-A monoclonal thyroid-stimulating antibody
• Pharmacokinetics and biodistribution of genetically engineered antibodies
• Monoclonal antibodies in immune and inflammatory diseases
• Antibody discovery-phage display
• Anti-R7V antibodies as therapeutics for HIV-infected patients in failure of HAART
• Monoclonal antibodies as therapeutics in oncology
• Antibody discovery-the use of transgenic mice to generate human monoclonal antibodies for therapeutics
• Monoclonal antibody manufacturing in transgenic plants ?a myths and realities
• boundless potential, daunting challenges
• Anti-human epidermal growth factor receptor 2 monoclonal antibody therapy for breast cancer

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Catalytic Antibody

• catalytic antibodies-
• catalytic antibodies Functional mimicry between anti-Tendamistat antibodies and α-amylase
• catalytic antibodies Immunologically driven chemical engineering of antibodies for catalytic activity
• A method for the detection and screening of catalytic anti-DNA antibodies
• Antibodies with hydrolytic activity towards factor VIII in patients with hemophilia
• Anticocaine catalytic antibodies
• Catalytic antibodies in clinical and experimental pathology
• Catalytic antibodies with acetylcholinesterase activity
• Evolution of catalytic antibody repertoire in autoimmune
• Detection strategies for catalytic antibodies
• Human catalytic RNA-and DNA-hydrolyzing antibodies
• catalytic antibodies-Idiotypic network mimicry and antibody
• Prospects for immunotherapeutic proteolytic antibodies
• structure and mechanism of action of hydrolytic antibody 7F11, an aspartate rich relation of catalytic antibodies 17E8 and 29G11
• Polyclonal catalytic antibodies
• Prospects for immunotherapeutic proteolytic antibodies
• Reactive immunization-a unique approach to catalytic antibodies
• The use of enzyme immunoassays for the detection of abzymatic activities. Application to an enantioselective thioacetal hydrolysis activity
• The elicitation of carboxylesterase activity in antibodies by reactive immunization with labile organophosphorus antigens
• Selective chemotherapeutic strategies using catalytic antibodies
• Targeted destruction of the HIV-1 coat protein gp41 by a catalytic antibody light chain
• Idiotypic mimicry of a catalytic antibody active site

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Cytokines In Autoimmune Disease ＆ chronic inflammatory

• Cytokines in autoimmune disease and chronic inflammatory
• Cytokines and anti-cytokine biologicals in autoimmunity
• Death receptor Fas and autoimmune disease
• IL-2 and autoimmune disease
• IL-6 in autoimmune disease
• Regulation of cytokine signaling and inflammation
• Role of TNF-TNFR in autoimmunity
• Roles of IL-1 in the development of rheumatoid arthritis
• The balance between IL-1 and IL-1Ra in disease
• The role of interleukin-10 in autoimmune disease
• Type I interferons and autoimmunity

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• Cytokines and Cancer
• A new partner for inhibitory Smads
• Alternate signalling pathways from the interleukin-2 receptor
• Chemokine receptors
• Chemokines in cancer
• Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors
• IGM-CSF-based cellular vaccines-a review of the clinical experience
• INF and cancer
• Interferon-alpha in tumor immunity and immunotherapy
• Interleukin-12 in anti-tumor immunity and immunotherapy
• Interleukin-2 and interleukin-15-immunotherapy for cancer
• Interleukin-6 and prostate cancer progression
• Interleukin-8 and human cancer biology
• Mechanism of BLyS action in B cell immunity
• Molecules that function in the steps of fertilization
• Oncolytic viruses and cancer therapy
• Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition
• roles of IFN in protection against tumor development and cancer immunoediting
• The ephrins and Eph receptors in angiogenesis
• The ever-increasing complexity of TGF-signaling
• The GDNF-RET signaling pathway and human diseases
• The role of the activin-follistatin system in the developmental and regeneration processes of the kidney
• Thrombopoietin-a pan-hematopoietic cytokine
• Tumor necrosis factor or tumor promoting factor
• Type I interferons and limitin-a comparison of structures, receptors, and functions

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• multifaceted roles of lipids and their catabolites in immune cell signaling
• Phosphoinositide 3-kinase in immunological systems
• Phospholipase D and immune receptor signalling
• Protein kinase B (Akt) regulation and function in T lymphocytes
• Regulation of the immune response by SHIP
• Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN
• Sphingolipids and the regulation of the immune response

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• Lymphocyte activation and effector functions
• Lymphocyte activation and effector functions-1
• Communication between the TCR and integrins
• Control of adaptive immune responses by Toll-like receptors
• Formation and function of the immunological synapse -
• Influence of effector molecules on the CD8+ T cell response to infection
• Interferon-producing cells
• Lymphocyte activation via NKG2D
• Molecular mechanisms of activated T cell death in vivo
• Negative co-receptors on lymphocytes
• New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
• novel B7 family members regulate effector T cell responses
• Protein kinase C-θ- signaling from the center of the T-cell synapse
• Regulation of B cell fates by BCR signaling components
• Scaffolds, adaptors and linkers of TCR signaling
• T helper cell differentiation
• The T-cell receptor signalosome

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• Lymphocyte activation and effector functions
• Lymphocyte activation and effector functions-1
• Communication between the TCR and integrins
• Control of adaptive immune responses by Toll-like receptors
• Formation and function of the immunological synapse -
• Influence of effector molecules on the CD8+ T cell response to infection
• Interferon-producing cells
• Lymphocyte activation via NKG2D
• Molecular mechanisms of activated T cell death in vivo
• Negative co-receptors on lymphocytes
• New insights into the regulation and functions of Tec family tyrosine kinases in the immune system
• novel B7 family members regulate effector T cell responses
• Protein kinase C-θ- signaling from the center of the T-cell synapse
• Regulation of B cell fates by BCR signaling components
• Scaffolds, adaptors and linkers of TCR signaling
• T helper cell differentiation
• The T-cell receptor signalosome

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• Autoimmune diseases-are markers ready for prediction
• Dendritic cells in autoimmune diseases
• Fc-receptors in autoimmune diseases
• Gene therapy in autoimmune disease
• Autoimmune type 1 diabetes-resolved and unresolved issues
• Chemokines in autoimmune disease
• Dendritic cells in autoimmune diseases
• Immunopathogenesis of cholestatic autoimmune liver diseases
• Is obsessive–compulsive disorder an autoimmune disease
• i-The common genetic hypothesis of autoimmune-inflammatory disease
• Maternal Antibodies, Childhood Infections, and Autoimmune Diseases
• Mechanisms for the induction of autoimmunity by infectious agents
• On the Role of the Innate Immunity in Autoimmune Disease
• Organ-specific Autoimmune Disease
• Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease
• autoimmunity-Effector lymphocytes in autoimmunity
• autoimmunity-Insights into autoimmunity gained from structural analysis of MHC_peptide complexes
• autoimmunity-Thyroid autoimmunity
• imm-Autoimmune-Current Concepts in the Diagnosis, Pathogenesis, and Treatment of Autoimmune Hepatitis
• imm-autoimmune-Antigen-specific immunotherapy for autoimmune disease
• Antigen-specific immunotherapy for autoimmune disease
• Immunology-DNA drives autoimmunity

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Nutrients and immune

• Nutrients as regulators of immune function-Introduction
• distinct role for apoptosis in the changes in lymphopoiesis and myelopoiesis created by deficiencies in zinc
• Leptin regulation of the immune response and the immunodeficiency of malnutrition
• Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through Toll-like receptor 4-derived signaling pathways
• Vitamin D-its role and uses in immunology

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抗原提呈与识别

• Antigen processing and recognition
• closer look at proteolysis and MHC-class-II-restricted antigen presentation
• Interactions between MHC molecules and co-receptors of the TCR
• The specificity of TCR-pMHC interaction
• Trafficking of MHC class II molecules in the late secretory pathway
• Roles of heat-shock proteins in antigen presentation and cross-presentation
• So many ways of getting in the way- diversity in the molecular architecture of superantigen-dependent T-cell signaling complexes

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免疫细胞

• Cellular signaling in macrophage migration and chemotaxis
• Leukocyte antimicrobial peptides
• leukocyte-Regulation of hematopoiesis through adhesion receptors
• Chronic granulomatous disease- more than the lack of superoxide
• Heterogeneity of human peripheral blood monocyte subsets
• Lymphoid neogenesis- novo formation of lymphoid tissue chemokines
• MAP kinase activation in macrophages
• Regulation of hematopoiesis through adhesion receptors
• Src kinase-mediated signaling in leukocytes
• The role of architectural transcription factors in cytokine gene transcription
• Transcriptional regulation of lymphocyte
• Leukocyte antimicrobial peptides
• leukocyte-Regulation of hematopoiesis through adhesion receptors
• Chronic granulomatous disease- more than the lack of superoxide
• Heterogeneity of human peripheral blood monocyte subsets
• Lymphoid neogenesis- novo formation of lymphoid tissue chemokines
• MAP kinase activation in macrophages
• Regulation of hematopoiesis through adhesion receptors
• Src kinase-mediated signaling in leukocytes
• The role of architectural transcription factors in cytokine gene transcription
• lyukocytes-Transcriptional regulation of lymphocyte
• T cell fate specification and αβ-γδ lineage commitment
• Generation and maintenance of memory T cells
• In vivo tracking of tumor-specific T cells
• Molecular determinants of TCR expression and selection
• Signal strength in thymic selection and lineage commitment
• Stability and commitment in T helper cell development
• Promiscuous expression of tissue antigens in the thymus- a key to T-cell tolerance and autoimmunity
• The role of Gamma deltaT cells in the airways
• Evasion of host cell defense mechanisms by pathogenic bacteria
• Chemokines in lymphopoiesis and lymphoid organ development
• Co-option of endocytic functions of cellular caveolae by pathogens
• CROSS-PRESENTATION, DENDRITIC CELLS, TOLERANCE AND IMMUNITY
• CTLA-4-MEDIATED INHIBITION IN REGULATION OF T CELL RESPONSES- Mechanisms and Manipulation in Tumor Immunotherapy
• Dendritic cells resurrect antigens from dead cells
• Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
• Differential processing of class-I-restricted epitopes by the standard proteasome and immunoproteasome
• Divergent and convergent evolution of NK-cell receptors
• Effector and regulatory T cells in allergic contact dermatitis
• Gene expression physiology and pathophysiology of the immune system
• Generation and maintenance of memory T cells
• Human memory T cells- lessons from stem cell transplantation
• IN VIVO ACTIVATION OF ANTIGEN-SPECIFIC CD4 T CELLS
• In vivo tracking of tumor-specific T cells
• Lymphocyte development Editorial overview
• Modulating the immune response with dendritic cells and their growth factors
• T cell fate specification and - lineage commitment
• TB vaccines- progress and problems
• Role of CD30+ T cells in rheumatoid arthritis
• The role of molecules that mediate apoptosis in T-cell selection
• Notch1 and T-cell development- insights from conditional knockout mice
• The role of TALL-1 and APRIL in immune regulation
• Pluripotent hematopoietic stem cell development during embryogenesis
• Transcription factor regulation of B lineage commitment
• Transcriptional regulation in lymphocytes
• Viral vectors for dendritic cell-based immunotherapy
• Towards an understanding of somatic hypermutation
• REGULATION OF THE NATURAL KILLER CELL RECEPTOR REPERTOIRE
• THE BARE LYMPHOCYTE SYNDROME AND THE REGULATION OF MHC EXPRESSION
• Selection events operating at various stages in B cell development
• SPECIFICITY AND DEGENERACY IN ANTIGEN RECOGNITION- Yin and Yang in the Immune System
• Stability and commitment in T helper cell development
• B CELL DEVELOPMENT PATHWAYS
• B1 cells- similarities and differences with other B cell subsets

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细胞因子

• elicobacter pylori genetic diversity and risk of human disease
• Aspects of Lyme Borreliosis in Europe
• HIV versus the immune system
• HIV-1 Sequence Variation
• Microbial Pathogenesis of Mycobacterium tuberculosis
• New Insights into Host Factors in HIV-1 Pathogenesis
• viral appropriation of the NF-kB pathway
• A novel bioadhesive intranasal delivery system for inactivated influenza vaccines
• Adverse metabolic consequences of HIV protease inhibitor therapy
• Pathogenesis and host response in Helicobacter infections
• Hijacking and exploitation of IL-10 by intracellular pathogens
• Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling
• Regulation of G1 phase progression by growth factors and the extracellular matrix
• The TNF and TNF Receptor Superfamilies- Integrating Mammalian Biology
• Cell identification and isolation on the basis of cytokine secretion
• IL-15 and IL-2- a matter of life and death for T cells in vivo
• Cut