Comet assay(彗星测定)

        Comet assay也称为单细胞凝胶电泳测定技术，它是一种敏感单链或双链DNA突变和破损的遗传测定方法。基于DNA损伤和修复在遗传、生化、细胞生物学和疾病发病中意义，Comet assay已经广泛应用于DNA损伤，细胞凋亡，基因毒理，放射损伤，危险因子，生物标记物鉴定等多个领域，是一个值得推广和应用的分子生物学和细胞生物学分析方法。由于损伤的DNA在电场的作用下，向阳极移动，在荧光显微镜下可以见到一个明亮的头和一条弥散的尾，酷似一颗彗星，故而得名。现CMBI特摘录了相关论文，供大家参考。更多文献，请用相关关键词通过CMBI文献查询获取。

• A novel statistical approach for the evaluation of comet assay data
• A quantitative comet assay
• Analysis of genotoxic potentiality of stevioside by comet assay
• Antioxidants and the Comet assay
• DNA Damage and Repair Detected by The Comet Assay in Lymphocytes
• Ecotoxicological applications and significance of the comet assay
• Impact of the comet assay in radiobiology
• Investigating oxidative DNA damage and its repair using the comet assay
• Low sensitivity of the comet assay to detect acetaldehyde-induced genotoxicity
• New applications of the Comet assay
• Potential use of the comet assay in the clinical management of cancer
• Statistical issues in the use of the comet assay
• The comet assay as an indicator test for germ cell genotoxicity
• The Comet assay for the evaluation of genotoxic impact in aquatic environments
• The comet assay in human biomonitoring-gene–environment interactions
• The comet assay_topical issues
• The effect of inhibited replication on DNA migration in the comet assay in relation to cytotoxicity and clastogenicity
• The use of the comet assay in the study of human nutrition and cancer
• Using the alkaline comet assay in prognostic tests for male infertility and assisted reproductive technology outcomes